Tianeptine decreases both serotonin transporter
mRNA and binding sites in rat brain

by
Kuroda Y, Watanabe Y, McEwen BS.
Laboratory of Neuroendocrinology,
Rockefeller University, New York, NY 10021.
Eur J Pharmacol. 1994 Jun 15;268(1):R3-5.


ABSTRACT

In situ hybridization histochemistry and quantitative autoradiography were used to evaluate the effects of repeated administration of the serotonin reuptake enhancer, tianeptine. Tianeptine (10 mg/kg twice daily, for 14 days) significantly reduced both the expression of serotonin transporter mRNA and serotonin transporter binding sites labeled by [3H]paroxetine in rat dorsal raphe nucleus. In median raphe nucleus, tianeptine did not change either expression of serotonin transporter mRNA or binding. This effect, which is similar to a reported effect for serotonin reuptake inhibitors, may help to explain the antidepressant effect of tianeptine.
Metabolism
Long-term use
Neuroplasticity
Pharmacodynamics
Serotonin/forebrain
Tianeptine (Stablon)
Tianeptine: structure
Melancholic depression
Stress, memory and depression
Tianeptine for anxious depressives
Electrophysiological effects of tianeptine
Tianeptine (Stablon) versus fluoxetine (Prozac)
Antidepressant comparisons: SSRIs v tianeptine


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