Efficacy of tianeptine in comparative trials
versus reference antidepressants. An overview
by
Guelfi JD. Clinique des Maladies Mentales et de l'Encephale,
Paris, France.
Br J Psychiatry Suppl. 1992 Feb;(15):72-5.

ABSTRACT

The clinical properties of tianeptine have been assessed in double-blind controlled studies, which involved depressed patients fulfilling DSM-III criteria for either major depression--single episode or recurrent (without melancholia and psychotic features)--or dysthymic disorder--with or without an additional diagnosis of alcohol abuse or dependence. Five studies have compared tianeptine with reference antidepressants: its efficacy has been found to be similar to that of amitriptyline in depressed out-patients. However, these data need to be confirmed by other controlled trials v. reference drugs and by at least two placebo-controlled studies. Tianeptine does not induce sleep disorders, anticholinergic effects, or modifications of cardiovascular variables or biological parameters (renal, haematological, or hepatic). After the end of treatment, the only signs of withdrawal have been some disturbances of sleep.

Depression
Neuroplasticity
Asthma prevention
Anxious depression
Tianeptine (Stablon)
Tianeptine: structure
Apoptosis prevention
Dopamine and neuroplasticity
Tianeptine and Panic Disorder
Ethanol withdrawal and tianeptine
Discriminative stimulus properties
Neurobiology of mood, anxiety and emotion
Serotonin reuptake facilitator and antidepressant
Major depression treated with tianeptine (Stablon)

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