Tianeptine therapy for depression in the elderly
Saiz-Ruiz J, Montes JM, Alvarez E, Cervera S, Giner J,
Guerrero J, Seva A, Dourdil F, Lopez-Ibor JJ.
Hospital Ramon y Cajal, Madrid, Spain.
Prog Neuropsychopharmacol Biol Psychiatry. 1998 Feb;22(2):319-29.


1. Depression is frequent in the elderly but difficult both to diagnose and treat due to a number of distinctive features. 2. Tianeptine is a novel antidepressant with a reverse mode of action to that of the selective serotonin reuptake inhibitors yet with proven efficacy and safety. 3. 63 elderly patients (mean age:68.8 years; range:65-80 years) with depressive symptoms (major depression:55.6%; dysthymia:44.4%) were included in a 3-month open multicenter study with tianeptine (25 mg daily). 4. 43 patients (68.2%) completed the study. There were no drop-outs due to side-effects. Total Montgomery and Asberg Depression Rating Scale scores were significantly decreased (p < 0.01) on day 14, with a response rate of 76.7%. 5. Improvements were also observed in anxiety and cognitive performance. Side-effects were seen in only 11.7% of patients, with no changes in laboratory or ancillary safety parameters. Tianeptine is thus effective and well tolerated in this category of patient.
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