Acute stress-induced changes in hippocampal/prefrontal
circuits in rats: effects of antidepressants

Rocher C, Spedding M, Munoz C, Jay TM.
NAMC, CNRS UMR 8620, Bat. 446,
Universite Paris-Sud,
91405 Orsay, France.
Cereb Cortex. 2004 Feb;14(2):224-9.


Acute stress inhibits long-term potentiation (LTP) at synapses from the hippocampus to prefrontal cortex in the rat, a model of the dysfunction in the anterior cingulate/orbitofrontal cortices which has been observed in human depression. We demonstrate that the antidepressants tianeptine and, to a lesser extent, fluoxetine, are able to reverse the impairment in LTP, a measure of frontal synaptic plasticity, caused by stress on an elevated platform. LTP was induced by stimulation of hippocampal outflow. Beneficial effects on neuronal plasticity, defined as a reversal of the effects of stress in this paradigm, can be considered as a new animal model for the impact of stress on hippocampal/frontal circuits, a key target in psychiatric diseases.
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