Pre-training administration of tianeptine, but not propranolol, protects hippocampus-dependent memory from being impaired by predator stress
by
Campbell AM, Park CR, Zoladz PR, Muñoz C, Fleshner M, Diamond DM.
Medical Research, VA Hospital, 13000 Bruce B. Downs Blvd.,
Tampa, FL, USA;
Department of Psychology,
University of South Florida,
4202 E. Fowler, Ave.,
PCD 4118G, Tampa, FL, USA.
Eur Neuropsychopharmacol. 2007 Jun 11;
ABSTRACTExtensive research has shown that the antidepressant tianeptine blocks the adverse effects of chronic stress on hippocampal functioning. The current series of experiments extended this area of investigation by examining the influence of tianeptine on acute stress-induced impairments of spatial (hippocampus-dependent) memory. Tianeptine (10 mg/kg, ip) administered to adult male rats before, but not after, water maze training blocked the amnestic effects of predator stress (occurring between training and retrieval) on memory. The protective effects of tianeptine on memory occurred in rats which had extensive pre-stress training, as well as in rats which had only a single day of training. Tianeptine blocked stress effects on memory without altering the stress-induced increase in corticosterone levels. Propranolol, a beta-adrenergic receptor antagonist (5 and 10 mg/kg, ip), in contrast, did not block stress-induced amnesia. These findings indicate that treatment with tianeptine, unlike propanolol, provides an effective means with which to block the adverse effects of stress on cognitive functions of the hippocampus.Long-term use
Neuroplasticity
Pharmacodynamics
Serotonin/forebrain
Tianeptine (Stablon)
Tianeptine: structure
Melancholic depression
Stress, memory and depression
Tianeptine for anxious depressives
Electrophysiological effects of tianeptine
Treatment-resistant depression: therapies
Tianeptine (Stablon) versus fluoxetine (Prozac)
Antidepressant comparisons: SSRIs v tianeptine
Tianeptine (Stablon) v paroxetine (Paxil, Seroxat)
Tianeptine (Stablon) to treat depressive symptoms in Parkinson's disease
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