Effects of tianeptine on learning and memory in mice. Improvement of impairments induced by chronic alcoholism and brain aging
Jaffard R, Mocaer E, Lebrun C, Beracochea D.
Laboratoire de Neurosciences Comportementales et Cognitives,
URA CNRS, Universite de Bordeaux I, Talence.
Presse Med. 1991 Nov 14;20(37):1812-6.
ABSTRACTTianeptine, a molecule with antidepressant properties, was found to affect certain learning and memory impairments induced by chronic alcoholism and aging in the mouse. Impairment in spontaneous alternation induced by chronic (12 months) alcohol intake and accelerated loss of spatial learning skills related to aging disappeared totally after administration of tianeptine (10 mg.kg-1). In certain situations (discrimination acquisitions), tianeptine was uneffective in older animals at this dosage, but had a facilitating effect in young animals. The effects of tianeptine on serotonin mediated transmission and the probable implication of hypofunctioning central cholinergic systems in the observed impairments are discussed. Tianeptine might reduce the inhibiting action of serotonin terminaisons on acetylcholine release and might thus permit normal cholinergic transmissionNeuroplasticity
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