Neuro-electrophysiologic studies in abstinent and depressed alcoholic patients treated with tianeptine
by
Macher JP, Minot R, Duval F, Luthringer R,
Toussaint M, Schaltenbrand N.
C.H.S., Rouffach.
lPresse Med. 1991 Nov 14;20(37):1853-7.


ABSTRACT

A concerted study of the clinical and electrophysiologic effects of tianeptine was conducted in alcoholic patients hospitalized for 5 weeks for alcohol withdrawal cures and subsequent depression. Because of the well known manifestations of infraclinical cognition impairment, sleep disorders and greater susceptibility to undesirable effects of psychotropic drugs, which hinder health care in this type of patient, the authors investigated changes in cognitive functions and the effect of tianeptine on sleep organization and daytime vigilance. Results after 4 weeks treatment (3 times 12.5 mg/day) included: besides its antidepressant effect, tianeptine reduces the manifestations of anxiety, without sedation effects, either clinical or electrophysiologic; tianeptine has no deleterious effect on cognitive functions, on the contrary, it appears to favour recovery when they are impaired; tianeptine does not modify sleep structure, notably in paradoxal sleep; tianeptine is an antidepressant which has a good acceptability, even for a population at "risk".
EEG
Depression
Metabolism
Opiate users
Long-term use
Serotonin/forebrain
Tianeptine (Stablon)
Tianeptine: structure
Memory consolidation
Stress, memory and depression
Tianeptine for anxious depressives
Tianeptine-induced serotonin uptake increase
Tianeptine and accelerated serotonin reuptake
Tianeptine reduces proinflammatory cytokine production


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