Neurobiology of mood, anxiety, and emotions as revealed by studies of a unique antidepressant: tianeptine
by
McEwen BS, Olie JP.
Harold & Margaret Milliken Hatch Laboratory of Neuroendocrinology,
The Rockefeller University,
New York, NY 10021, USA.
mcewen@mail.rockefeller.edu
Mol Psychiatry. 2005 Jun;10(6):525-37.


ABSTRACT

Recent studies have provided evidence that structural remodeling of certain brain regions is a feature of depressive illness, and the postulated underlying mechanisms contribute to the idea that there is more to antidepressant actions that can be explained exclusively by a monoaminergic hypothesis. This review summarizes recent neurobiological studies on the antidepressant, tianeptine (S-1574, [3-chloro-6-methyl-5,5-dioxo-6,11-dihydro-(c,f)-dibenzo-(1,2-thiazepine)-11-yl) amino]-7 heptanoic acid, sodium salt), a compound with structural similarities to the tricyclic antidepressant agents, the efficacy and good tolerance of which have been clearly established. These studies have revealed that the neurobiological properties of tianeptine involve the dynamic interplay between numerous neurotransmitter systems, as well as a critical role of structural and functional plasticity in the brain regions that permit the full expression of emotional learning. Although the story is far from complete, the schema underlying the effect of tianeptine on central plasticity is the most thoroughly studied of any antidepressants. Effects of tianeptine on neuronal excitability, neuroprotection, anxiety, and memory have also been found. Together with clinical data on the efficacy of tianeptine as an antidepressant, these actions offer insights into how compounds like tianeptine may be useful in the treatment of neurobiological features of depressive disorders.
Antidepressant
Neuroplasticity
Synaptic plasticity
Asthma prevention
Anxious depression
Tianeptine (Stablon)
Tianeptine: structure
Tianeptine and Panic Disorder
Stress, memory and depression
Ethanol withdrawal and tianeptine
Discriminative stimulus properties
Stress-induced hippocampal atrophy and dysfunction
Tianeptine enantiomers and serotonin-induced behaviour


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