Efficacy and tolerability of coaxil (tianeptine) in the
therapy of posttraumatic stress disorder

Aleksandrovskii IuA, Avedisova AS, Boev IV,
Bukhanovkskii AO, Voloshin VM, Tsygankov BD, Shamrei BK.
Zh Nevrol Psikhiatr Im S S Korsakova. 2005;105(11):24-9.


The results of a multicenter study of coaxil in the treatment of 90 patients with posttraumatic stress disorder (PTSD) are summarized. Two dosages of the drug, 75 mg daily (44 patients) and 37.5 mg daily (46 patients) have been compared. Coaxil efficacy was estimated with the Clinician Administered PTSD Scale (CAPS) and Hamilton depression scale (HAM-D). High efficacy of coaxil was shown, with 76.7 and 75.6% responders, respectively, for the dosages used. The optimum one proved to be 37.5 mg daily, which is congruent to the standard dose in the treatment of depression and provides not only the efficacy but tolerability of coaxil. The coaxil efficacy depended on a PTSD type: the drug was more effective in chronic PTSD that, in the authors' opinion, might be related to its antidepressant action.

Acute effects
Tianeptine drivers
Synaptic plasticity
Anxious depression
Tianeptine (Stablon)
Tianeptine: structure
Tianeptine and Panic Disorder
Ethanol withdrawal and tianeptine
Discriminative stimulus properties
Tree-shews, cortisol and the hippocampus

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