Synaptic plasticity and tianeptine:
structural regulation

by
Fuchs E, Czeh B, Michaelis T,
de Biurrun G, Watanabe T, Frahm J.
Division of Neurobiology,
German Primate Center,
Kellnerweg 4, 37077 Gottingen, Germany.
efuchs@gwdg.de
Eur Psychiatry. 2002 Jul;17 Suppl 3:311-7


ABSTRACT

Stress-induced structural and cellular alterations in the hippocampus can contribute to the pathophysiology of depression. The reversal of these alterations may be a mechanism by which antidepressants achieve their therapeutic effect. The aim of the present study was therefore to investigate the effect of tianeptine on stress-induced structural changes and alterations in cerebral metabolites. To this end, psychosocially stressed male tree shrews were treated with tianeptine. A combination of in vivo and postmortem methods was used to evaluate the antidepressant treatment on the preservation of neuronal plasticity. It was found that all stress-induced effects were prevented by the administration of tianeptine. It is concluded that these findings provide experimental evidence for recent theories that impairment of neuronal viability and neuroplasticity might be important causal factors in mood disorders, suggesting tianeptine as a potential stimulator of neural resilience.


Aging mice
Neuroplasticity
Asthma prevention
Anxious depression
Tianeptine (Stablon)
Tianeptine: structure
Tianeptine and Panic Disorder
Stress, memory and depression
Ethanol withdrawal and tianeptine
Discriminative stimulus properties
Stress/5-HT1A and 5-HT2 receptors
Tianeptine prevents dendritic atrophy
Tree-shews, cortisol and the hippocampus
Neurobiology of mood, anxiety and emotion
Effect of tianeptine on growth hormone secretion
Major depression and impaired structural plasticity


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