Tianeptine treatment induces regionally
specific changes in monoamines

by
Frankfurt M, McKittrick CR, McEwen BS, Luine VN.
Laboratory of Neuroendocrinology,
Rockefeller University,
New York, NY 10021, USA.
Brain Res. 1995 Oct 23;696(1-2):1-6.


ABSTRACT

Tianeptine is an atypical tricyclic antidepressant that facilitates serotonin (5-HT) reuptake. Tianeptine (10 mg/kg) or saline was administered intraperitoneally to male rats daily for 4 days. Monoamine levels were measured in micropunches of discrete brain nuclei that are implicated in mood and cognition. In addition, the rates of 5-HT and norepinephrine (NE) accumulation were determined by the pargyline method. Few changes were noted in the 5-HT system. 5-HT levels were increased by short-term tianeptine in the CA3 region of hippocampus, and 5-hydroxyindoleacetic acid (5-HIAA) was increased in the ventromedial nucleus of hypothalamus, while 5-HT turnover was decreased in preoptic area (POA). In addition, short-term tianeptine treatment increased NE levels in POA, parietal sensory cortex (SCTX) and dorsal raphe (DR), and decreased NE in dentate gyrus. NE turnover was also decreased in DR, SCTX and parietal motor cortex. These data suggest that the short-term neural and behavioral actions of tianeptine may be attributable, in part, to alterations of the norepinephrine system.
Tianeptine
Metabolism
Long-term use
Neuroplasticity
Serotonin/forebrain
Tianeptine (Stablon)
Tianeptine: structure
Melancholic depression
Stress, memory and depression
Tianeptine for anxious depressives
Electrophysiological effects of tianeptine
Antidepressant comparisons: SSRIs v tianeptine
Tianeptine (Stablon) v paroxetine (Paxil, Seroxat)
Tianeptine (Stablon) and the alpha1-adrenergic receptors


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