Repeated stress causes reversible impairments
of spatial memory performance
Luine V, Villegas M, Martinez C, McEwen BS.
Department of Psychology,
Hunter College, New York, NY 10021.
Brain Res. 1994 Mar 7;639(1):167-70.
ABSTRACTRestraint stress, 6 h/day for 21 days, caused an impairment, during acquisition, of the performance of a spatial memory task, the eight-arm radial maze. The impairment was reversible, temporally limited and blocked by phenytoin, a blocker of excitatory amino acid action, or tianeptine, an antidepressant, which lowers extracellular serotonin. These effects on behavior parallel the reversible stress-induced atrophy of dendrites of hippocampal CA3 neurons that are also blocked by the drugs.Analgesic
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