Pharmacokinetic and pharmacodynamic interaction between the antidepressant tianeptine and oxazepam at steady-state
Toon S, Holt BL, Langley SJ, Mullins FG, Rowland M,
Halliday MS, Salvadori C, Delalleau B.
Medeval, University of Manchester, UK.
Psychopharmacology (Berl). 1990;101(2):226-32.


To assess if any pharmacokinetic or pharmacodynamic interaction at steady-state occurs between the new antidepressant tianeptine and a benzodiazepine (oxazepam) following multiple oral dosing of both drugs, 12 healthy male volunteers entered a balanced three-way double blind cross-over study. Tianeptine (12.5 mg) and/or oxazepam (10 mg) were given three times daily for 4 days. Pharmacokinetic data within a dosing interval at steady-state showed that there were no statistically significant changes in the pharmacokinetics of either tianeptine (and its two major metabolites) or oxazepam when both drugs were co-administered. Psychometric data showed that there was no synergistic negative interaction between the two drugs and that their combination may result in beneficial effects on "alertness" and "happiness".

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