The efficacy and safety of tianeptine in the treatment of depressive disorder: results of a controlled double-blind multicentre study vs. amitriptyline
Invernizzi G, Aguglia E, Bertolino A, Casacchia M,
Ciani N, Marchesi GF, Nardini M, Rapisarda V.
Clinica Psichiatrica dell'Universita di Milano,
Policlinico F. Sforza, Italia.
Neuropsychobiology. 1994;30(2-3):85-93.


Three hundred in- and outpatients suffering from depressive disorder, as diagnosed using DSM-III criteria were treated for 6 weeks under double-blind conditions in a multicenter controlled study of tianeptine vs. amitriptyline. Both groups presented steady improvement of depressive syndrome from day 7 up to the end of the treatment, as shown by all evaluation scales: HDRS, SAD, CGI. Furthermore, anxiety linked to the depressive syndrome decreased equally in both groups, as shown by the HARS measurements. In addition to the improvement of mood, the tianeptine-treated patients presented less somatic complaints and side effects when compared to the reference antidepressant. These results confirm previous findings that tianeptine is an effective antidepressant with a lower side effect profile than amitriptyline.
Amitriptyline (Elavil)
Tianeptine (Stablon)
Tianeptine: structure
Melancholic depression
Serotonin neurotransmission
Stress, memory and depression
Tianeptine for anxious depressives
Electrophysiological effects of tianeptine
Antidepressant comparisons: SSRIs v tianeptine
Tianeptine (Stablon) v paroxetine (Paxil, Seroxat)

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