Tianeptine, a specific serotonin uptake enhancer,
decreases ethanol intake in rats

by
Daoust M, Compagnon P, Legrand E, Mocaer E.
Faculte de Medecine et de Pharmacie de Rouen,
Saint Etienne du Rouvray, France.
Alcohol Alcohol. 1992 Jan;27(1):15-7.


ABSTRACT

The effect on ethanol intake of the selective 5-HT uptake enhancer tianeptine was examined in rats and compared with that of fluoxetine, a specific 5-HT uptake inhibitor. Both treatments significantly decreased ethanol intake (54% by tianeptine and 57% by fluoxetine). Fluoxetine also decreased food intake whereas tianeptine did not. Body weight was decreased by 12.5% in fluoxetine-treated rats but was not modified by tianeptine. It is proposed that tianeptine has a specific action on ethanol intake, possibly related to its effect on serotonin function.
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