Tolerability of tianeptine in 170 patients
with depression treated during one year

Loo H, Ganry H, Marey C, Briole G, Castelnau D, Charbonnier JF,
Dachary JM, Danion JM, Darcourt G, Capdeville C, et al.
Service Hospitalo-Universitaire de Sante Mentale et de Therapeutique,
Hopital Sainte-Anne, Paris.
Encephale. 1990 Nov-Dec;16(6):445-52.


Tianeptine, a new antidepressant, has a tricyclic molecular structure. Its main biochemical activity consists of an increase in the reuptake of 5 HT both in men and animals, after acute and chronic administration. Tianeptine demonstrated its antidepressive clinical efficacy in several double-blind versus reference drug trials. A multicentre open trial, including depressed patients enabled us to evaluate the safety of tianeptine and to control the maintenance of the therapeutic efficacy in the course of its long-term prescription. Depressed patients included showed a major depressive episode, single (296.22) or recurrent (296.32) without melancholia or psychotic features, or a dysthymic disorder (300.40), according to DSM III criteria. A minimum MADRS score of a least 25, and the informed consent of the patients were required. The dose of tianeptine was 3 tablets per day (12.5 mg/tablet) with the possibility of increasing to 4 or decreasing to 2 tablets per day, depending on the symptomatology. Therapeutic efficacy was evaluated by item 1 and 2 of the Global Clinical Impression (CGI), the Montgomery and Asberg Depression Rating Scale (MADRS), the Hamilton Anxiety Rating Scale (HARS) and the Hopkins Symptom Check-List (HSCL). Clinical and paraclinical safety were evaluated by CGI item 3, standardized ratings of patients' complaints (CHESS 84), interruption for side effects, evaluation of blood pressure, weight, biological parameters, EKGs. This intermediate evaluation concerns the first 170 depressed patients treated over a one-year period as well as the total group of patients included (n = 447).
Acute effects
Long-term use
Anxious depression
Tianeptine (Stablon)
Tianeptine: structure
Ethyl alcohol + tianeptine
Discriminative stimulus properties
Ultra-high dose psychostimulant effect
Tianeptine (Stablon, Coaxil) for alcoholics

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