Therapy resistant major depression: improvement of symptomatology after combining antidepressants with Tianeptine (Stablon)
Niederhofer H.
Univ.-Klinik fur Psychiatrie,
Abt. fur Kinder- und Jugendpsychiatrie,
Innsbruck, Austria.
Psychiatr Prax. 2003 May;30(4):221-2.


OBJECTIVES: In common, depressive disorders are treated with various antidepressants, the number of which is enormously increasing. Nevertheless, in some cases therapy resistance is observed. In these cases, neuroleptics are used as an alternative. Recently, Tianeptin (Stablon) has also been used for the treatment of depressive disorders. METHOD: We report a 32-year old "therapy resistant" depressive female. Monotherapy with antidepressants and Tianeptin (Stablon) was ineffective. RESULTS: Finally, a combination of antidepressants and Tianeptin (Stablon) was effective and lowered the HAMD-Score significantly. DISCUSSION: A combination of antidepressants and Tianeptin (Stablon) seems to be an effective new Option for the treatment of "therapy resistant" major depressions.
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Antidepressant comparisons: SSRIs v tianeptine
Tianeptine (Stablon) v paroxetine (Paxil, Seroxat)
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