Tianeptine increases brain-derived neurotrophic factor
expression in the rat amygdala

Reagan LP, Hendry RM, Reznikov LR, Piroli GG,
Wood GE, McEwen BS, Grillo CA.
Department of Pharmacology, Physiology and Neuroscience,
University of South Carolina School of Medicine,
6439 Garner's Ferry Road, D40, Columbia,
SC 29208, United States.
Eur J Pharmacol. 2007 Feb 20;


Chronic restraint stress affects hippocampal and amygdalar synaptic plasticity as determined by electrophysiological, morphological and behavioral measures, changes that are inhibited by some but not all antidepressants. The efficacy of some classes of antidepressants is proposed to involve increased phosphorylation of cAMP response element binding protein (CREB), leading to increased expression of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF). Conversely, some studies suggest that acute and chronic stress downregulate BDNF expression and activity. Accordingly, the aim of the current study was to examine total and phosphorylated CREB (pCREB), as well as BDNF mRNA and protein levels in the hippocampus and amygdala of rats subjected to chronic restraint stress in the presence and absence of the antidepressant tianeptine. In the hippocampus, chronic restraint stress increased pCREB levels without affecting BDNF mRNA or protein expression. Tianeptine administration had no effect upon these measures in the hippocampus. In the amygdala, BDNF mRNA expression was not modulated in chronic restraint stress rats given saline in spite of increased pCREB levels. Conversely, BDNF mRNA levels were increased in the amygdala of chronic restraint stress/tianeptine rats in the absence of changes in pCREB levels when compared to non-stressed controls. Amygdalar BDNF protein increased while pCREB levels decreased in tianeptine-treated rats irrespective of stress conditions. Collectively, these results demonstrate that tianeptine concomitantly decreases pCREB while increasing BDNF expression in the rat amygdala, increases in neurotrophic factor expression that may participate in the enhancement of amygdalar synaptic plasticity mediated by tianeptine.
The amygdala
Long-term use
Tianeptine (Stablon)
Tianeptine: structure
Melancholic depression
Antidepressant comparisons
Stress, memory and depression
Tianeptine for anxious depressives
Therapy-resistant major depression
Electrophysiological effects of tianeptine
Long-term trial of the antidepressant tianetine
Antidepressant comparisons: SSRIs v tianeptine
Tianeptine (Stablon) v paroxetine (Paxil, Seroxat)
Major depression treated with tianeptine (Stablon)

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